Publikationen / Patente

Publikationen

Huck S, Bock J, Giardello J, Gauert M, Pul Ü: Marker-free genome editing in Ustilago trichophora with the CRISPR-Cas9 technology. RNA Biol, 16 (4): 397-403 (2019)

Trothe J, Ritzmann D, Lang V, Scholz P, Pul Ü, Kaufmann R, Buerger C, Ertongur-Fauth T: Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume-regulated anion channels. Exp Dermatol, 27 (12): 1352-1360 (2018)

Pul Ü, Mampel J, Zurek C, Krohn M: CRISPR in der biotechnologischen Forschung und Entwicklung. BioSpektrum 22 (01): 61-64 (2016)

Pul Ü: Chemical and enzymatic footprint analyses of R-loop formation by Cascade-crRNA complex. Methods Mol Biol, 1311: 293-305 (2015)

Arslan Z, Hermanns V, Wurm R, Wagner R, Pul Ü: Detection and characterization of spacer integration intermediates in type I-E CRISPR-Cas system. Nucl Acids Res, 42 (12), 7884-7893 (2014)

Marchfelder A, Maier L, Heidrich N, Pul Ü: Das Immunsystem der Prokaryoten: CRISPR-Cas. BiuZ, 43(3), 158-165 (2013)

Arslan Z, Wurm R, Brener O, Ellinger P, Nagel-Steger L, Oesterhelt F, S-chmitt L, Willbold D, Wagner R, Gohlke H, Smits SHJ, Pul Ü: Double-strand DNA end-binding and sliding of the toroidal CRISPR-associated protein Csn2. Nucl Acids Res, 41 (12), 6347-6359 (2013)

Arslan Z, Stratmann T, Wurm R, Wagner R, Schnetz K, Pul Ü: RcsB-BglJ mediated activation of Cascade operon does not induce the maturation of CRISPR RNAs in E. coli K12. RNA Biol. 10 (5), 708-715 (2013)

Arslan Z, Westra ER, Wagner R, Pul Ü: Regulation of CRISPR-based immune responses. In: CRISPR-Cas systems: RNA-mediated Adaptive Immunity in Bacteria and Archaea, Barrangou, Rodolphe; van der Oost, John (Eds.) , Springer-Verlag X, 93-113 (2013)

Wagner R, Pul Ü: CRISPR – a bacterial immunity system based on small RNAs In: From Nucleic Acids Sequences to Molecular Medicine. Eds. V.A. Erdmann and J. Barciszewski, Springer-Verlag IX, 121-143 (2012)

Ellinger P, Arslan Z, Wurm R, Ries B, MacKenzie C, Pfeffer K, Panjikar S, Wagner R, Schmitt L, Gohlke H, Pul Ü, Smits SHJ: The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiae. J. Struct. Biol. 178 (3), 350-62 (2012)

Jore MM, Lundgren M, van Duin E, Bultema JB, Westra ER, Waghmare SP, Wiedenheft B, Pul Ü, Wurm R, Wagner R, Beijer M, Barendregt RA, Zhou K, Snijders APL, Dickman MJ, Doudna JA, Boekema EJ, Heck AJR, van der Oost J, Brouns SJJ: Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nat. Struc. Mol. Biol. 18: 529–536 (2011)

Westra ER, Pul Ü, Heidrich N, Jore MM, Lundgren M, Stratmann T, Wurm R, Raine A, Mescher M, van Heereveld L, Mastop M, Wagner EGH, Schnetz K, van der Oost J, Wagner R and Brouns SJJ: H-NS mediated repression of CRISPR-based immunity in Escherichia coli K12 can be relieved by the transcription activator LeuO. Mol. Microbiol. 77: 1380–1393 (2011). Highlighted in: Mol Microbiol. 2010 Sep;77(6):1341-5

Wagner R, Pul Ü: Mikrobielles “Immunsystem”: Abwehr gegen Fremd-DNA durch das bakterielle CRISPR/Cas-System. BioSpektrum 17 (04): 393-395 (2011)

Pul Ü, Wurm R, Arslan Z, Geißen R, Hofmann N, Wagner R: Identification and Characterization of E. coli CRISPR-cas Promoters and their Silencing by H-NS. Mol. Microbiol. 75:1495-1512 (2010)

Patentanmeldungen

Pul Ü, Pelzer A – B.R.A.I.N AG: A Method For Engineering A Protein, PCT/EP2019/060,139

Pul Ü, Ertongur-Fauth T, Gründer S., Trothe J – B.R.A.I.N AG: Enrichment of genome-edited cells, WO/2019/202099

Naumer C., Zurek, C, Pul Ü: WeissBiotech GmbH: Enzyme Product with Beta-Galactosidase, WO/2018/229259

Pul Ü, Krohn M – B.R.A.I.N AG: Activation of taste receptor genes in mammalian cells using CRISPR-Cas9, granted, WO/2017/050963

Pul Ü, Mampel J, Zurek, C, Rehdorf, J, Krohn M – B.R.A.I.N AG: Reconstitution of DNA-end repair pathway in prokaryotes, WO/2017/109167

www.crispr.de